Modern vapes — particularly disposables and pod systems at 5% (50 mg/mL) — deliver nicotine with extreme efficiency. Many vapers take hundreds of puffs per day, compared to the 100–200 puffs a pack-a-day smoker takes. This constant micro-dosing creates a more even nicotine level in the blood, which means withdrawal can feel more persistent and harder to distract from than cigarette withdrawal.
The good news: the pharmacological timeline is the same. Nicotine clears the body within 72 hours regardless of the source. After that, physical withdrawal declines steadily.